Medicine information
Uses & overview
TRIGLICLAGLAZE 60 by Steris Healthcare brings together three complementary anti-diabetic agents: Gliclazide Sustained Release (60 mg), Pioglitazone (15 mg), and Metformin Hydrochloride Sustained Release (500 mg). This triple-action formulation targets three core pathophysiological defects in type 2 diabetes—impaired beta-cell insulin secretion, peripheral insulin resistance, and excessive hepatic glucose output. Key Uses & Clinical Benefits: Comprehensive Glycemic Control: Offers effective, multi-pathway regulation of both fasting and postprandial blood glucose levels to help patients achieve target HbA1c levels. Stimulates Natural Insulin Secretion: Gliclazide SR (a second-generation sulfonylurea) acts on pancreatic beta-cells to boost mealtime insulin release. Reduces Insulin Resistance: Pioglitazone works as a PPAR-gamma agonist to enhance insulin sensitivity in muscle and adipose tissues, facilitating cellular glucose uptake. Decreases Hepatic Glucose Production: Metformin reduces glucose synthesis in the liver, lowers intestinal glucose absorption, and improves peripheral insulin response. Sustained-Release Formulation: The Sustained Release (SR) mechanism of Gliclazide (60 mg) and Metformin (500 mg) ensures smooth, steady therapeutic activity throughout the day while reducing gastrointestinal irritation. How TRIGLICLAGLAZE 60 Works: Gliclazide SR (60 mg): Selectively binds to sulfonylurea receptors on pancreatic beta-cells to stimulate controlled insulin release. Pioglitazone (15 mg): Improves insulin sensitivity directly at the receptor level in fat and muscle tissues. Metformin SR (500 mg): Decreases hepatic gluconeogenesis and optimizes cellular glucose utilization.
How to use
Take 1 tablet of TRIGLICLAGLAZE 60 daily with meals (preferably during breakfast or the main meal of the day) or as directed by your physician. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as doing so disrupts the sustained-release properties of the formulation.
Storage
Store in a cool, dry place away from direct sunlight, light, and moisture. Maintain at a controlled room temperature below 30°C. Keep out of reach and sight of children.
