Medicine information
उपयोग
ST-GLIPTIN M 50/500 by Steris Healthcare combines two proven blood sugar-lowering agents: Sitagliptin (50 mg) and Metformin Hydrochloride Sustained Release (500 mg). By pairing a DPP-4 inhibitor with a biguanide, this dual-combination therapy targets type 2 diabetes through two complementary mechanisms—boosting glucose-dependent insulin release and enhancing insulin sensitivity in peripheral tissues. Key Uses & Clinical Benefits: Dual-Action Glycemic Control: Effectively lowers both fasting and postprandial (post-meal) blood glucose levels, helping patients maintain target HbA1c goals. Incretin Enhancement: Sitagliptin (a DPP-4 inhibitor) prolongs the active life of naturally occurring incretin hormones (GLP-1 and GIP), boosting natural insulin release after meals while suppressing excessive glucagon. Reduces Hepatic Glucose Production: Metformin SR decreases glucose production in the liver, reduces intestinal glucose absorption, and enhances insulin sensitivity in muscle cells. Sustained-Release Formulation: The 500 mg Sustained Release (SR) Metformin matrix ensures steady drug delivery over time, minimizing common gastrointestinal side effects like stomach upset and nausea. Low Risk of Hypoglycemia & Weight-Neutral Profile: Works via glucose-dependent pathways, delivering reliable glycemic control with a low risk of low blood sugar spikes and no added body weight gain. How ST-GLIPTIN M 50/500 Works: Sitagliptin (50 mg): Prevents the breakdown of incretin hormones by the DPP-4 enzyme, increasing mealtime insulin production and curbing excess glucagon release. Metformin SR (500 mg): Activates AMP-activated protein kinase (AMPK) in liver tissue to suppress gluconeogenesis and optimize cellular response to circulating insulin.
कैसे उपयोग करें
Take 1 tablet of ST-GLIPTIN M 50/500 once or twice daily with meals (preferably with breakfast or dinner) or as directed by your physician. Taking the medication with food helps minimize potential gastrointestinal discomfort associated with Metformin. Swallow the tablet whole with a glass of water—do not crush, chew, or break the tablet, as doing so disrupts the sustained-release delivery mechanism.
भंडारण
Store in a cool, dry place away from direct sunlight, light, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
