Medicine information
उपयोग
CARDULES ISMN SR 40 by Steris Healthcare delivers 40 mg of Isosorbide Mononitrate in a specialized Sustained Release (SR) formulation. Engineered for predictable daily anti-anginal protection, this oral organic nitrate provides a smooth, controlled release of active medication over several hours, maintaining steady blood levels to prevent exertional chest pain while strategically guarding against nitrate tolerance. Key Uses & Clinical Benefits: Angina Pectoris Prevention: Effectively reduces the frequency, duration, and severity of chronic stable chest pain episodes caused by narrowed coronary arteries. Sustained Release Technology: Designed to release the drug continuously over an extended period, ensuring consistent hemodynamic stability and preventing sudden blood pressure fluctuations. Reduces Myocardial Workload: Dilates peripheral veins and arteries, reducing venous return (preload) and systemic vascular resistance (afterload), which significantly decreases the heart's oxygen demand. Prevents Nitrate Tolerance: Formulated to support an eccentric once-daily dosing regimen that maintains an essential daily "nitrate-free interval" to preserve vascular responsiveness. Improves Exercise Tolerance: Enables patients with chronic stable angina to participate in daily physical activities with diminished chest discomfort and breathlessness. How CARDULES ISMN SR 40 Works: Isosorbide Mononitrate is metabolized to generate Nitric Oxide (NO) in vascular smooth muscle cells. Nitric oxide activates guanylate cyclase to increase intracellular cyclic Guanosine Monophosphate (cGMP), inducing vascular smooth muscle relaxation. This leads to marked venous dilation, reduced cardiac filling pressures, and enhanced blood delivery across collateral coronary vascular beds.
कैसे उपयोग करें
Take 1 tablet of CARDULES ISMN SR 40 once daily in the morning, or strictly as prescribed by your cardiologist or physician. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as doing so destroys the sustained-release mechanism. Taking your dose consistently at the same time every morning ensures a natural nitrate-free period during rest and sleep hours.
भंडारण
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
